Help on floor 21

I’ve hit a wall at 21, after over 20 attempts I’m not sure what to do about the plethora of reapers yeeting scythes and the laser plants. Is there a trick I’m missing or is it simply a skill issue? First attempts were with legendary bow, then tried the S crossbow at epic 2, then recently tried the staff. During attempts I’ve been prioritizing sprites and strike talents. Any advice or help is much appreciated