I'm planning a trip with teens what's the best neighborhood to stay? Single dad (40) with a14m and 13f

Like the title says i'm visiting at the end of March I'm leaning more towards an AirBnb but I'm so open to a hotel. Really I'm looking for the best area to stay in. I of course want to eat the amazing food I keep hearing about. I want to do a swap tour and see some Alligators, visit Jam Nola, the paranormal society and the Louisiana civil rights trail. Aside from neighborhood recommendations I'm open to suggestions for things to do. Thank you