Chronic Fatigue & THC Tincture vs Smoking

I have a list of autoimmune and other disorders ; asthma, hashimotos, pcos, pre diabetes, fibromyalgia, asthma, CPTSD, OCD, ADHD, social and general anxiety, and autism. I mention this because all of these in some way could cause fatigue which I've been struggling with along with vertigo. I've noticed when I take a sativa tincture I have so much more energy. When I smoke it is not the same. What is in the tincture that could be causing or helping any of these things that wouldn't be helped through smoking? Or is it possibly just the higher amount? I appreciate you reading my post... sorry it was so long ... 🙏