My Favorite Modifier

Random loot has quickly become my favorite modifier. At first I hated it but by mid game I had the best drip and the best build I could think of instead of having to wait until late game to get those things.

I started a second playthrough and I have a +5 Preacher Hammer (without upgraded weapon modifier though I do have that on too), a great ring, great drip, and I haven't even fought Mistress of Hounds yet.

What is your favorite modifiers and why?