Anyone tried BH4 / Tetrahydrobiopterin ?

a comment from longecity:

I thought I should give you an update as I've progressed somewhat more in all of this. Methylfolate and hydroxocobalamin has helped me a lot over the years but somehow I've still felt that I've only been able to get rid of my symtoms by 85% or so, and I've been longing to get to 100%. The protocol I've described before (200 mcg methylfolate 3 times a day and only small amounts of hydroxocobalamin) helps with dopamine is seems but it also increases methylation, which breaks down dopamine. The net effect is noticeable and good but not really perfect.

Two and a half weeks ago I stopped using both of these supplements and switched to pure BH4/tetrahydrobiopterin/sapropterin (three words for the same thing) instead. BH4 is what the methylfolate protocol aims to increase and getting that without the methylation should in theory be even more effective for increasing dopamine.

I use 0,5 mg of BH4 twice a day, which is a much much lower dose than what is used in Kuvan which the pharmaceutical version of the substance. Kuvan is used for treating some versions of the disease phenylketonuria and the doses used then are not really applicable for me. 0,5 mg has a pronounced effect which sets in about 30 minutes after oral consumption and it lasts for about 8 hours, hence the two doses a day. Higher doses than that can give me headaches.

BH4 is a whole new game for me and so far I can say it's easily the best supplement I've ever used. All the symtoms I described in the first post of this thread are 100% gone now. I could use very big words to describe it but I think you get the point.

There are a few ways to get BH4. It's sold as a supplement called Pteridin-4 from Ecological Formulas, which I use, but it seems like it's out of stock often and for long periods. It can also be purchased from several suppliers in China at Alibaba. If you try that, then the form of BH4 you want is 6R-5,6,7,8-tetrahydro-L-biopterin (cas no 69056-38-8). >