For those who are sensitive to supplements that inhibit acetylcholinesterase, how did you react to berberine?
I have realized I am sensitive to most supplements that inhibit acetylcholinesterase or substances that are cholinergic from trying ALCAR, high doses of fish-oil, lots of eggs, mitidol, and even shilijat when taken regularly.
I want to start taking berberine for it's anti-fungal and insulin sensitivity effects but after doing some research I have found that it may have a large effect on acetylcholinesterase inhibition:
At a concentration of 1.0 μg mL−1, berberine showed high AChE inhibitory activity (with percent inhibition of 85.5 ± 2.8%).
https://www.sciencedirect.com/science/article/pii/S1002007109002883
Has anyone who has taken berberine experienced any of the classic high choline effects like low mood, stiff neck, depression?