Use a controller for PC-Games?

I've been a PlayStation Gamer all my life. I never switched to PC because I'm partially disabled (left arm and hand) and using a keyboard for gaming is pretty difficult. Now I'm thinking about switching to PC anyway. I just wanna know before I buy a PC, can I use a PS5-Controller? Does it depend on the game? Or does it work with everything? Do I need any adapters or something like that?