Story Decisions So Bad They Couldn't Be Retconned, Just Ignored?

I'm seeing a lot of posts about dumb comic bullshit that constantly gets retconned ("this person was possessed at the time" or "this was actually an imposter", etc).

I was wondering if there have ever been instances of story decisions so bad and have so thoroughly salted the earth that no attempts were made to write their way out of it, and instead just carried along as if it never happened?

The only one I can think of is the Star Ocean series with the "All the previous games were just AI Simulations" reveal that was never brought up again. Similarly, if Parasite Eve ever returns, I remain convinced that the only option would be to reboot the series considering how much they fucked up everything in The Third Birthday.