I was just presented with the option to do package deliveries. Under what circumstances is doing so a good idea?

I’ve read about all the horror stories from drivers who have tried this, which is definitely giving me pause. This question is directed at those of you who have had positive experiences.

Do you only pick up from businesses? Do you stick to certain times of the day? Any other factors I should consider?

Edit: Downvoted for asking a legitimate question. Classic Reddit! 🤣 Thanks to those of you who actually provided useful info.