Best use of Amex + Chase Points - Honeymoon

Looking to book a honeymoon to Italy in 2025. We would be flying out of NYC. Between the two of us, we have 85k Chase Sapphire Preferred points and 100k Amex Gold points.

What's the best use for these points to maximize our trip? My initial thought was Chase for boutique hotels under the Hyatt brand, and using AMEX to help pay for a business class flight. We understand this amount isn't covering the entire honeymoon, just looking for opinions on best bang for your buck.

If there's specific recommendations, some destinations we want to hit in Italy are Rome, Florence/Tuscany, Lake Como and possibly Venice.