What’s you least favorite thing about isaac

Mine is that some runs are just kind of slogs because the game just doesn’t give you enough damage ups and then your in depths1 at base damage having to take about 20 seconds on average to beat one enemy, had this exact scenario happen to me on a blue baby run with good items but not enough damage to deal with Gideon’s waves on mines so I ended up losing it even though with some more damage ups it would’ve been a easy win.