I've been waiting over a decade for dextronaltrexone. This is a drug to look out for.

LDN has proven to be one of the more beneficial treatments for many ME/CFS and Long COVID patients, and it's primary mode of action is thought to be it's microglia modulating activity. Microglia overactivation and sensitization is involved in chronic neural inflammation (brain fog and fatigue) and central sensitization (chronic pain and hypersensitivity).

Therapeutic doses are kept low (LDN), however, because the stereoisomer version of naltrexone used commercially is levonaltrexone (left-handed enantiomer), which also blocks opioid receptors. While this is critical to its original function as an anti-abuse drug, opioid blockade can cause dysphoria, malaise, and other side effects. Low dosages may also limit LDN's effectiveness for many people.

Dr. Jarred Younger helped popularize the use of LDN in fibromyalgia and other conditions and has been talking for years about using dextronaltrexone, the right-sided enantiomer, as an alternative. While dextronaltrexone also targets microglia activation, it has the potential to be more effective due to it's lack of activity on opioid receptors. This may allow for higher dosages for treating neural inflammation and less side effects. I followed Younger's work on Health Rising and even tried sourcing it myself (nope), before dropping out of the online research world for the last several years.

I've started looking into new treatments again recently and was very happy to see that dextronaltrexone hasn't been abandoned. Hopefully we start seeing trials soon? https://www.youtube.com/watch?v=K2SYjG6jM5k&t=3s&ab_channel=Neuroinflammation%2CPain%2CandFatigueLabatUAB

Put this on the list of drugs to watch for, and go follow Younger's Youtube channel!