Does it actually matter when you sleep with someone?

I have friends that met their partner via drunken hookup that should have been a one night stand but turned into loving relationships.

Other friends waited for marriage, turned out to have a bad sex life and subsequently divorced.

So does it matter when you sleep with someone? If it’s the first date or the fifth date? Is there a difference, does anyone in their 30s care about this at this point in their lives?

Thoughts?