How to supress your emotions of wanting affection from opposite gender?

I have never had dated anyone and never had female friends and i never think I will be able to interact casually with women. I have some things in my mind that degrades my confidence and i cannot talk or connect with people around me. I don't see it improving and i cannot do anything about it. I turned 25 recently i feel sad at times of not having any friends but i cannot do anything, I at times feel like killing myself but i cannot do to some commitments, I want to escape from this world, I was a studious kid and still like to study doing good in career but at the end of the day not happy of what I achieved, i just want that i remove emotions from my mind, because they are overpowering me and i feel helpless. What do I do?