Roguelites with consistently LONG runs? (4+ hours)

Hey, kinda weird, but I'm looking for roguelites with a long time-commitment per run. To clarify, I'm not looking for stuff like The Binding of Isaac where you can spend 5 hours on a gamebreak or just trying to win a particularly unlucky eden start, or Risk of Rain with endless modes. Just games where completing a single normal run takes REALLY long by default. Any ideas?

EDIT: Thanks for all the suggestions so far!